Keacy Carty and Brandon King both scored centuries as West Indies cantered home in pursuit of 264 with seven overs to spare.
Carty blitzed his way to his maiden international ton in 97 balls and stayed unbeaten on 128, while King made his third ODI century in 113 balls.
England’s 263/8 had looked reasonably healthy considering they crumbled to 24/4 in 10 overs. Phil Salt’s watchful 74 dug them out of a hole with Sam Curran scoring 40 and Dan Mousley impressing with his maiden ODI half-century.
Jamie Overton added 32 while Jofra Archer remained unbeaten on 38 as England recovered to post a total which had looked challenging until the intervention of King and Carty.
Will England get their revenge when the two sides meet again on Thursday 29 May at Edgbaston in 2025? Experience it for yourself with Early Bird tickets now available, offering a saving of at least £5 per ticket. "It's a big plus for us, the work is really showing. The guys are putting a lot of work in off the field. It's a great confidence booster, especially for the batting unit."
"We are missing a lot of players. We have a lot of people to come back into the team. Hopefully the younger boys that haven't played that much international cricket have learned a lot."
With Jos Buttler returning as captain, England will hope to regroup as they prepare for a five-match T20 series, which begins at the same venue on Saturday.